For practitioners
How Regenis delivers what conventional injectors block.
Regenerative biostimulators are suspensions of solid microspheres. Conventional injector needles are specified for solutions. This page sets out the delivery problem that follows, and the engineering Regenis uses to address it.
The failure mode
Microspheres pack and bridge at the needle hub.
Where the hub narrows into the cannula, suspended microspheres can accumulate faster than they clear. The result is a partial or complete occlusion that changes delivery mid-procedure.
Why it happens
Manual reconstitution does not distribute evenly.
Biostimulator microspheres are solid and denser than their carrier, so they settle. How thoroughly a syringe is mixed by hand determines how evenly the dose is distributed — and that varies between operators and between passes.
- One regulated feed
- Distribution chamber
- Nine needles, one application
Schematic cross-section, not to scale. Redrawn from the manufacturer's sectional view, Hertz Biotechnology (Shenzhen).
Sensing and control
Five signals, sampled continuously, resolved in a closed loop.
Sensors integrated into the handpiece report at millisecond intervals. The control model reads all five together and adjusts drive output while the injection is in progress, rather than after it.
Perception
- Negative pressure
- Thrust force
- Speed
- Current
- Torque
Control model — on-device
Quad-core ARM CPU with a dedicated AI processing unit. Injection planning, clogging warning and risk analysis run on a real-time operating system.
Actuation
- Power
- Rotation direction
- Speed
Sensors report at millisecond intervals; drive output is adjusted while the injection is in progress.
Protected design
The anti-clogging mechanism is patented.
The delivery path is the subject of a granted utility-model patent held by the manufacturer.
- Holder
- Hertz Biotechnology (Shenzhen) Co., Ltd.
- Title
- Microsphere injection anti-clogging device
- Application number
- 202421307575.3
- Filed
- 7 June 2024
Precision and interlocks
The system reports when delivery is not nominal.
Nine needles share one regulated feed, so coverage is uniform across the treated area. When the drive train meets resistance outside its expected envelope, the system raises a named alarm rather than continuing silently.
- Alarm states
- Low suction pressure · Handle disconnected · Pusher blocked
- Needle array
- Nine-needle, uniform coverage
- Applied part
- IEC Type B
- Negative pressure
- Up to 90 kPa, 10 levels
In the treatment room
Built to be handled through a full clinic day.
Weight, cleaning and consumable handling determine whether a device is used or left in a cupboard.
- Handpiece weight
- 212 g
- Filtration
- Sterile negative-pressure tubing, triple filtration
- Line cleaning
- One-touch vacuum line cleaning, 750 ml/min
- Memory presets
- Eight
- Handpiece dock
- Magnetic
- Noise
- < 52 dB
Range covered
Specified for biostimulators and conventional mesotherapy solutions.
The delivery path is designed around the thicker suspensions that block conventional injectors, without excluding the lighter formulations already in routine use.
- Biostimulators
- PDLLA · PLLA · PCL · CaHA
- Mesotherapy solutions
- Basic · Nutritional · Functional
Specifications
Engineering specifications
- Display
- 13.3" HD touchscreen
- Control hardware
- Quad-core ARM CPU + AI processing unit
- Operating system
- Real-time Linux
- Motor durability
- 1.6 million injection cycles
- Cable
- Rated to 100,000 connection cycles
- Compliance
- GB 9706.224-2021 · YY 9706.108-2021
References
The delivery challenges described on this page are documented in the peer-reviewed dermatology literature. These sources are listed so practitioners can review the primary material directly.
- Lin J-Y, Lin C-Y. Needle clogging in biostimulator injection: rheological context and clinical experience. Journal of Cosmetic Dermatology. 2026;25(2). PMC12859172
- Magacho-Vieira FN, et al. Consensus recommendations for the reconstitution and aesthetic use of poly-D,L-lactic acid microspheres. Clinical, Cosmetic and Investigational Dermatology. 2024;17:2755–2765. doi:10.2147/CCID.S497691
- Lin C-Y, et al. Early-stage volume effect difference between injectable poly-L-lactic acid and injectable poly-D,L-lactic acid. Journal of Cosmetic Dermatology. 2023. doi:10.1111/jocd.15595
